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S-Adenosyl methionine
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S-Adenosyl methionine : ウィキペディア英語版
S-Adenosyl methionine

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''S''-Adenosyl methionine〔SAM-e, SAMe, SAM, S-Adenosyl-L-methionine, AdoMet, ademetionine〕 is a common cosubstrate involved in methyl group transfers, transsulfuration, and aminopropylation. Although these anabolic reactions occur throughout the body, most SAM is produced and consumed in the liver.〔 More than 40 methyl transfers from SAM are known, to various substrates such as nucleic acids, proteins, lipids and secondary metabolites. It is made from adenosine triphosphate (ATP) and methionine by methionine adenosyltransferase (). SAM was first discovered in Italy by Giulio Cantoni in 1952.
In bacteria, SAM is bound by the SAM riboswitch, which regulates genes involved in methionine or ()] biosynthesis.
== Biochemistry of ''S''-adenosyl methionine ==


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